Prior infection, vaccines provide best protection from COVID-19

A new study in two states that compares coronavirus protection from prior infection and vaccination concludes getting the shots is still the safest way to prevent COVID-19.

The study examined infections in New York and California last summer and fall and found people who were both vaccinated and had survived a prior bout of COVID-19 had the most protection.

But unvaccinated people with a prior infection were a close second. By fall, when the more contagious delta variant had taken over but boosters weren’t yet widespread, those people had lower diagnoses than vaccinated people who had no past infection.

The Centers for Disease Control and Prevention, which released the study Wednesday, noted several caveats to the research. And some outside experts were cautious of the findings and wary of how they might be interpreted.

“The bottom line message is that from symptomatic COVID infection you do generate some immunity," said immunologist E. John Wherry of the University of Pennsylvania. “But it’s still much safer to get your immunity from vaccination than from infection.”

Vaccination has long been urged even after a prior case of COVID-19 because both kinds of protection eventually wane — and there are too many unknowns to rely only on a past infection, especially a long-ago one, added immunologist Ali Ellebedy at Washington University in St. Louis.

“There are so many variables you cannot control that you just cannot use it as a way to say, ‘Oh, I’m infected then I am protected,’” Ellebedy said.

The research does fall in line with a small cluster of studies that found unvaccinated people people with a previous infection had lower risks of COVID diagnosis or illness than vaccinated people who were never before infected.

The findings do seem plausible, said Christine Petersen, a University of Iowa epidemiologist. She said a vaccine developed against an earlier form of the coronavirus is likely to become less and less effective against newer, mutated versions.

However, she and other experts said, there are a number of possible other factors at play, including whether the vaccine’s effectiveness simply faded over time in many people and to what extent mask wearing and other behaviors played a part in what happened.

CDC officials noted the study was done before the omicron variant took over and before many Americans received booster doses, and so it’s not clear what impact boosters might have. The analysis also did not address the risk of severe illness or death from COVID-19.

The study authors concluded vaccination “remains the safest strategy" to prevent infections and “all eligible persons should be up to date with COVID-19 vaccination."

The researchers looked at infections in California and New York, which together account for about 18% of the U.S. population. They also looked at COVID-19 hospitalizations in California.

Overall, about 70% of the adults in each state were vaccinated; another 5% were vaccinated and had a previous infection. A little under 20% weren’t vaccinated; and roughly 5% were unvaccinated but had a past infection.

The researchers looked at COVID-19 cases from the end of last May until mid-November, and calculated how often new infections happened in each group.

Compared with unvaccinated people who hadn’t been diagnosed with COVID-19, case rates were:

— 6-fold lower in California and 4.5-fold lower in New York in those who were vaccinated but not previously infected.

— 29-fold lower in California and 15-fold lower in New York those who had been infected but never vaccinated.

— 32.5-fold lower in California and 20-fold lower in New York in those who had been infected and vaccinated.